GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs56322409 | 1 | rs11188396 | chr10:97367510 | ENTPD1 | chr10:97471536-97637022:+ | 0.19 | 4.99 | 9.3E-7 | Blood metabolite levels |
| BLCA | cis | rs56322409 | 1 | rs11188398 | chr10:97369093 | ENTPD1 | chr10:97471536-97637022:+ | 0.19 | 4.99 | 9.3E-7 | Blood metabolite levels |
| BLCA | cis | rs56322409 | 1 | rs11188400 | chr10:97371327 | ENTPD1 | chr10:97471536-97637022:+ | 0.19 | 4.99 | 9.3E-7 | Blood metabolite levels |
| BLCA | cis | rs56322409 | 1 | rs11188406 | chr10:97390195 | ENTPD1 | chr10:97471536-97637022:+ | 0.19 | 4.92 | 1.32E-6 | Blood metabolite levels |
| BLCA | cis | rs56322409 | 1 | rs11188407 | chr10:97390533 | ENTPD1 | chr10:97471536-97637022:+ | 0.19 | 4.92 | 1.32E-6 | Blood metabolite levels |
| BLCA | cis | rs56322409 | 1 | rs11188411 | chr10:97397344 | ENTPD1 | chr10:97471536-97637022:+ | 0.2 | 5.13 | 4.67E-7 | Blood metabolite levels |
| BLCA | cis | rs56322409 | 1 | rs11188417 | chr10:97411680 | ENTPD1 | chr10:97471536-97637022:+ | -0.2 | -5.14 | 4.35E-7 | Blood metabolite levels |
| BLCA | cis | rs6951245 | 1 | rs111899361 | chr7:1112348 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.47 | 1.05E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs11190179 | 1 | rs11190172 | chr10:101358381 | CNNM1 | chr10:101088856-101154085:+ | 0.34 | 3.87 | 0.000128 | β2-Glycoprotein I (β2-GPI) plasma levels |
| BLCA | cis | rs11190179 | 1 | rs11190178 | chr10:101363457 | CNNM1 | chr10:101088856-101154085:+ | 0.34 | 3.86 | 0.000135 | β2-Glycoprotein I (β2-GPI) plasma levels |
| BLCA | cis | rs80285556 | 1 | rs111902838 | chr19:50496614 | SIGLEC16 | chr19:50472912-50479075:+ | 0.59 | 5.59 | 4.36E-8 | antipsychotic drug dosage in schizophrenia or schizoaffective disorder |
| BLCA | cis | rs11190604 | 1 | rs11190569 | chr10:102227409 | SEC31B | chr10:102246403-102289636:- | -0.21 | -3.84 | 0.000145 | Palmitoleic acid (16:1n-7) plasma levels |
| BLCA | cis | rs11191419 | 1 | rs11191419 | chr10:104612335 | AS3MT | chr10:104613967-104661653:+ | -0.31 | -5.72 | 2.14E-8 | Schizophrenia |
| BLCA | cis | rs11191419 | 1 | rs11191419 | chr10:104612335 | C10orf32 | chr10:104613967-104624718:+ | -0.31 | -5.53 | 6.08E-8 | Schizophrenia |
| BLCA | cis | rs4409766 | 1 | rs11191425 | chr10:104625970 | AS3MT | chr10:104613967-104661653:+ | -0.33 | -3.85 | 0.000138 | Hypertension;Systolic blood pressure;Diastolic blood pressure |